• Mindray Service Manual

. Konijn, Nicole P C; van Tuyl, Lilian H D; Boers, Maarten; den Uyl, Debby; Ter Wee, Marieke M; van der Wijden, Lindsey K M; Bultink, Irene E M; Kerstens, Pit J S M; Voskuyl, Alexandre E; van Schaardenburg, Dirkjan; Nurmohamed, Michael T; Lems, Willem F 2017-09-01 To assess the efficacy and safety of initial COBRA-light vs COBRA therapy in RA patients after a 4-year follow-up period. In the COBRA-light trial, 162 consecutive patients with recent-onset RA were randomized to either COBRA-light (prednisolone and MTX) or COBRA therapy (prednisolone, MTX and SSZ) for 1 year. After 1 year, treatment was continued without protocol, and adjusted by the treating physician according to clinical judgement, preferably with a treat-to-target strategy. Four years after trial initiation, all patients were invited to participate in the COBRA-light extension study, in which patients were interviewed and physically examined, patient reported outcomes were assessed, radiographs were made and clinical records were examined for comorbidities and medication use.

In the extension study, 149 out of 162 (92%) original trial patients participated: 72 COBRA-light and 77 COBRA patients. Initial COBRA-light and COBRA therapy showed similar effect on disease activity, physical functioning, radiological outcome and Boolean remission over the 4-year follow-up period. In addition, both treatment groups showed similar survival and major comorbidities, although the power to detect differences was limited. Besides protocolled differences in prednisolone, MTX and SSZ use, the use of other synthetic and biologic DMARDs and intra-articular and intramuscular glucocorticoid injections was similar in both treatment groups over the 4-year period. Early RA patients initially treated with COBRA-light or COBRA therapy had similar efficacy and safety outcomes over a 4-year follow-up period.

Mindray DECG-03A ECG. Std 3 lead, rhythm lead, 3/2 leads or manual 1 lead 80mm folded or rolled thermosensitive paper with effective 72mm width.

Durre, Ingeborg K.; Durre, Imke 1999-01-01 Describes an eight-dot computer Braille notation, COBRA, with integrated mathematical and scientific notation that achieves immediate print-Braille compatibility through one-to-one representation of letters and other characters. Text can be entered from the Braille or the Qwerty Keyboard and can be viewed simultaneously on the Braille display and.

Yuan, J. P.; Manchester, R.

Mindray Service Manual

N.; Wang, N.; Wang, J. B.; Zhou, X.; Yan, W. 2017-04-01 Pulse arrival time measurements over 14 yr with the Nanshan 25-m and Parkes 64-m radio telescopes have been used to determine the average profile and timing properties for PSR J1757-2421 (B1754-24). Analysis of the radio profile data shows a large variation of spectral index across the profile and an unusual increase in component separation with increasing frequency. The timing observations show that PSR B1754-24 underwent a large glitch with a fractional increase in spin frequency of Δνg/ν ∼ 7.8 × 10-6 in 2011 May. At the time of the glitch, there was a large permanent jump in the rotational frequency accompanied by two exponential recovery terms with time-scales of 15(6) and 97(15) d, respectively.

Lindner, J.; Lundberg, J.K.; Williams, R.M.; Leone, S.R. 1995-04-01 The signal-to-noise ratio in a time-resolved Fourier transform (FT) infrared emission experiment is improved by pulse-to-pulse normalization.

The signal from the FT spectrometer is normalized by the total infrared fluorescence produced on each laser pulse. A factor of 20 enhancement in signal-to-noise ratio is demonstrated with normalization when the fluctuation of the laser pulse energy is the dominant noise source. Applications are discussed pertaining to cases where other noise sources such as detector and amplifier noise cannot be neglected and when information from the time evolution of the spectrum is required. Ebrahim, Karim; Shirazi, Farshad H; Mirakabadi, Abbas Zare; Vatanpour, Hossein 2015-12-15 Organs homeostasis is controlled by a dynamic balance between cell proliferation and apoptosis. Failure to induction of apoptosis has been implicated in tumor development.

Cytotoxin-I (CTX-I) and cytotoxin-II (CTX-II) are two physiologically active polypeptides found in Caspian cobra venom. Anticancer activity and mechanism of cell death induced by these toxins have been studied. The toxins were purified by different chromatographic steps and their cytotoxicity and pattern of cell death were determined by MTT, LDH release, acridine orange/ethidium bromide (AO/EtBr) double staining, flow cytometric analysis, caspase-3 activity and neutral red assays. The IC50 of CTX-II in MCF-7, HepG2, DU-145 and HL-60 was 4.1 ± 1.3, 21.2 ± 4.4, 9.4 ± 1.8 μg/mL and 16.3 ± 1.9 respectively while the IC50 of this toxin in normal MDCK cell line was 54.5 ± 3.9 μg/mL. LDH release suddenly increase after a specific toxins concentrations in all cell lines. AO/EtBr double staining, flow cytometric analysis and caspase-3 activity assay confirm dose and time-dependent induction of apoptosis by both toxins.

CTX-I and CTX-II treated cells lost their lysosomal membrane integrity and couldn't uptake neutral red day. CTX-I and CTX-II showed significant anticancer activity with minimum effects on normal cells and better IC50 compared to current anticancer drug; cisplatin.

They induce their apoptotic effect via lysosomal pathways and release of cathepsins to cytosol. These effects were seen in limited rage of toxins concentrations and pattern of cell death rapidly changes to necrosis by increase in toxin's concentration. In conclusion, significant apoptogenic effects of these toxins candidate them as a possible anticancer agent. Carlson, B E; Liang, C; Bitzer, P; Christian, H 2015-01-01 Lightning discharge is a complicated process with relevant physical scales spanning many orders of magnitude. In an effort to understand the electrodynamics of lightning and connect physical properties of the channel to observed behavior, we construct a simulation of charge and current flow on a narrow conducting channel embedded in three-dimensional space with the time domain electric field integral equation, the method of moments, and the thin-wire approximation. The method includes approximate treatment of resistance evolution due to lightning channel heating and the corona sheath of charge surrounding the lightning channel. Focusing our attention on preliminary breakdown in natural lightning by simulating stepwise channel extension with a simplified geometry, our simulation reproduces the broad features observed in data collected with the Huntsville Alabama Marx Meter Array.

Some deviations in pulse shape details are evident, suggesting future work focusing on the detailed properties of the stepping mechanism. Key Points Preliminary breakdown pulses can be reproduced by simulated channel extension Channel heating and corona sheath formation are crucial to proper pulse shape Extension processes and channel orientation significantly affect observations PMID:26664815. Segbers, Marcel; Rizzo Sierra, Carlos V; Duifhuis, Hendrikus; Hoogduin, Johannes M 2010-08-01 A method to reduce the acoustic noise generated by gradient systems in MRI has been recently proposed; such a method is based on the linear response theory. Since the physical cause of MRI acoustic noise is the time derivative of the gradient current, a common trapezoid current shape produces an acoustic gradient coil response mainly during the rising and falling edge. In the falling edge, the coil acoustic response presents a 180 degrees phase difference compared to the rising edge. Therefore, by varying the width of the trapezoid and keeping the ramps constant, it is possible to suppress one selected frequency and its higher harmonics.

This value is matched to one of the prominent resonance frequencies of the gradient coil system. The idea of cancelling a single frequency is extended to a second frequency, using two successive trapezoid-shaped pulses presented at a selected interval. Overall sound pressure level reduction of 6 and 10 dB is found for the two trapezoid shapes and a single pulse shape, respectively. The acoustically optimized pulse shape proposed is additionally tested in a simulated echo planar imaging readout train, obtaining a sound pressure level reduction of 12 dB for the best case.

Johansson, A; Ahlstrom, C; Lanne, T; Ask, P 2006-06-01 In this study, we investigate the beat-to-beat respiratory fluctuations in pulse wave transit time (PTT) and its subcomponents, the cardiac pre-ejection period (PEP) and the vessel transit time (VTT) in ten healthy subjects. Download bully scholarship edition for pcsx2 system. The three transit times were found to fluctuate in pace with respiration. When applying a simple breath detecting algorithm, 88% of the breaths seen in a respiration air-flow reference could be detected correctly in PTT. Corresponding numbers for PEP and VTT were 76 and 81%, respectively. The performance during hypo- and hypertension was investigated by invoking blood pressure changes. In these situations, the error rates in breath detection were significantly higher.

PTT can be derived from signals already present in most standard monitoring set-ups. The transit time technology thus has prospects to become an interesting alternative for respiration rate monitoring. Wang, Dong; Yan, Lixin; Nie, Zan; Tian, Qili; Yang, Jin; Hua, Jianfei; Du, Yingchao; Huang, Wenhui 2017-06-01 In China, Tsinghua Thomson Scattering X-ray Source (TTX) is the dedicated hard X-ray source based on the Thomson scattering between a terawatt ultrashort laser and a relativistic electron beam. In the TTX, two synchronized Ti: sapphire laser systems generate the terawatt ultrashort infrared scattering laser and the ultraviolet driving laser for the photocathode RF gun to produce the electron beam; measuring the timing jitter between the electron beam and the laser beam is an essential task for the X-ray source. In the present study, we report on a single shot, non-collinear cross correlator with fs resolution and measured the timing jitter between the two synchronized laser systems with a pulse-to-pulse method, which is beneficial to estimate the jitter of the X-ray yield in the TTX system. Although it is more important to synchronize the scattering laser to the electron beam and not of the driving laser, the laser-laser jitter measurement would be a good first step towards that goal, and the result generated can be considered as the error signal for the potential feedback stabilization. Zhang, Li; Ding, Xinli; Wu, Zhe; Qian, Xiaoyan; An, Jianxiong; Tian, Ming 2017-02-01 Chronic pain often results in cognitive impairment.

Our previous study showed that trigeminal neuralgia induced by cobra venom leads to spatial learning and memory deficits, although the underlying mechanism remains unclear. However, recent evidence indicates that the c-AMP-responsive element binding protein (CREB)/brain derived neurotrophic factor (BDNF) pathway plays a critical role in various etiologies of cognitive deficits. Our aim was to explore the CREB/BDNF pathway to determine the molecular mechanisms involved in the pathogenesis of cognitive impairment caused by cobra venom-induced trigeminal neuralgia. A randomized, controlled animal study. Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University. Fifty male Sprague-Dawley rats were randomly divided into 3 groups: cobra venom group, sham group, and control group.

Cobra venom or saline was injected into the sheath of the infraorbital nerve (ION), respectively. Video recordings and mechanical thresholds were used to analyze changes in behavioral activity 3 days before surgery and 4, 7, 14, 21, 28, and 56 days after surgery. Morris water maze tests were conducted at 4- and 8-week time points after surgery to evaluate spatial learning and memory. We also investigated expression changes of phosphorylated CREB (p-CREB) and BDNF in the hippocampus and prefrontal cortex (PFC) using western blotting and immunohistochemistry.

Cobra venom-treated rats exhibited significant changes in face grooming, as well as exploratory and resting behaviors, compared with the control group and sham group (both P 0.05) in the first water maze protocol. In the second water maze test, rats in the cobra venom group exhibited spatial learning and memory deficits, with fewer platform site crossings during the probe trial (P 200 spike/s), VS values for 5,000- pulse/s trains were lower than those obtained with 250- pulse/s stimuli (even after accounting for the smaller periods of the 5,000- pulse/s stimuli), indicating a desynchronizing effect of high-rate stimuli. FF measures also indicated a desynchronizing effect of high-rate trains. Across a wide range of response rates, FF underwent relatively fast increases (i.e., within 100 ms) for 5,000- pulse/s stimuli. With a few exceptions, ISI, VS, and FF measures approached asymptotic values within the 300-ms duration of the low- and high-rate trains. These findings may have implications for designs of cochlear implant stimulus protocols, understanding electrically evoked compound action potentials, and interpretation of neural measures obtained at central nuclei, which depend on understanding the output of the auditory nerve. Drallmeier, J.

A.; Peters, J. 1986-04-01 An experimental program was conducted to measure drop sizes in pulsed sprays for diesel and fuel-injected spark ignition engine applications. A forward-scattering unit was designed with a high-speed data acquisition system to permit the measurement of drop sizes in sprays at 0.4-ms intervals. Data were taken at elevated pressures from 0.345 to 3.45 MPa with a 0-deg pintle nozzle. The Sauter Mean Diameter (SMD) and size distribution were calculated using a computational method that is independent of a predetermined distribution function. Results taken at the spray centerline indicate that for most elevated pressures, the SMD in the secondary injection region tended to increase as the pressure in the fuel line decreased and tended to increase with increasing environmental pressure, both suggesting an inverse relationship between drop size and the pressure drop across the nozzle.

Also as the environmental pressure was raised, the distribution width decreased at a slower rate than the SMD increased, indicating a spreading of the drop sizes with injection time at elevated pressures. Significant cycle-to-cycle variation in both the SMD and distribution width indicate that cycle-to-cycle variations must be considered in pulsed sprays. In addition, more variation was seen between random rather than consecutive cycles. Hayashi, Yujiro; Tanaka, Yoshihito; Kirimura, Tomoyuki; Ishikawa, Tetsuya; Tsukuda, Noboru; Kuramoto, Eiichi 2006-03-24 Acoustic pulse echoes generated by femtosecond laser irradiation were detected using time-resolved x-ray triple-crystal diffractometry. The determined time-dependent longitudinal strain component for pulse echoes in silicon and gallium arsenide plates showed that the polarity of the strain pulse was dependent on the optically induced initial stress, and that the bipolar pulse waveform was gradually deformed and broadened in the course of propagation. The three-dimensional wave front distortion of pulse echoes was shown simply as the pulse duration broadening, which was consistent with a boundary roughness for an unpolished plate.

Price - $1,500.00 + GST Product is 'New Old Stock'. Please contact us directly to enquire further or to purchase. Features. Automatic ECG measurement and analysis. Complete digital filter to avoid baseline drifting and interference from AC, EMG. Auto-adjusts baseline to optimize printing position.

Full digital processing. Simultaneous 12-lead acquisition. Thermal recorder with high resolution printing. Up to 4-hour battery working time.

Auto/manual operation mode. Lead-off detection and display. Selectable printing formats: Standard 3 leads, rhythm lead, 3/2 leads, manual 1 lead.

140 patient data storage. LCD Display (Narrow/Wide) selectable. It is vital to our practice to have equipment that we can rely on and feel confident in when it comes to making a diagnosis.

The power and quality of the Mindray M7Vet has not only allowed us to add additional services such as cardiology to our practice, it has also given our vets a greater level of assurance in understanding what they are viewing to make a confident diagnosis – even when only minor changes were present. Dr Paul May - BVSc.

(Surgery) Northern Veterinary Group, Kilmore and Wallan Veterinary Practices.